NSF award 2512961 · William Marsh Rice University

CRISPRai-regulated stress response modulation for cell factory engineering

Final report due

28 October 2029

in 1,106 days · The award ends on 30 June 2029.

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award ending 2029-06-30 · Research.gov
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Final report due28 Oct 2029in 1106 days
award ending 2029-06-30 · Research.gov
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Project outcomes report due28 Oct 2029in 1106 days
award ending 2029-06-30 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out28 Oct 2029in 1106 days
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So the final report is due by 28 October 2029.

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Award card

Award number: 2512961
Period of support: 1 Jul 2026 – 30 Jun 2029
Amount: $521,194
Awardee: William Marsh Rice University, Houston, TX
Program: Cellular & Biochem Engineering
Directorate: ENG

Abstract

Manufacturing therapeutic proteins is challenging. The cells that manufacture proteins often have low productivity and are difficult to culture in large volumes. Cell types with higher productivity can have issues surrounding proper folding and modification of the proteins. High productivity often leads to extreme metabolic stress. This can trigger a cascade of responses that result in cell death. This is a…

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