NSF award 2514394 · University of Delaware

BRING-SynBio: Deciphering and directing lactylation epigenetics to control macrophage immune cell phenotype

Final report due

29 December 2027

in 437 days · The award ends on 31 August 2027.

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award ending 2027-08-31 · Research.gov
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Extension request17 Jul 2027in 272 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice21 Aug 2027in 307 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 29 December 2027.

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Award card

Award number: 2514394
Period of support: 1 Sep 2025 – 31 Aug 2027
Amount: $300,000
Awardee: University of Delaware, Newark, DE
Program: Cellular & Biochem Engineering
Directorate: ENG

Abstract

Macrophages are immune cells that play critical roles in fighting disease, healing tissues, and maintaining overall health. Their behavior can shift in ways that either help or harm the body, depending on their environment. Histone lactylation, in which lactate, a small molecule metabolite produced in the body, changes how genes are turned on or off, may help explain how these cells change roles. This project will…

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