NSF award 2527296 · Johns Hopkins University

Collaborative Research: eMB: A deep learning-enhanced multiphysics and multiscale framework for mechanistic modeling of erythrophagocytosis

Final report due

29 December 2028

in 803 days · The award ends on 31 August 2028.

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Final report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2028in 803 days
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PAPPG 24-1: “financially closed out 120 days after their expiration date”

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So the final report is due by 29 December 2028.

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Award card

Award number: 2527296
Period of support: 1 Sep 2025 – 31 Aug 2028
Amount: $99,999
Awardee: Johns Hopkins University, Baltimore, MD
Program: MATHEMATICAL BIOLOGY
Directorate: MPS

Abstract

Erythrophagocytosis is a complex multiphysics process involving recognizing, engulfing, and digesting aged or diseased red blood cells (RBCs) by phagocytic cells. Biochemical signaling pathways mediated by ligand-receptor engagement have been considered as key factors in initiating and driving the phagocytosis of abnormal RBCs by tissue-resident macrophages in the spleen and the liver. However, growing evidence has…

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