NSF award 2530370 · Cleveland Clinic Foundation

Telomere End-Protection and the Anti-Checkpoint

Final report due

29 December 2028

in 803 days · The award ends on 31 August 2028.

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Decide about an extension3 May 2028in 563 days
award ending 2028-08-31 · Research.gov
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Extension request17 Jul 2028in 638 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice21 Aug 2028in 673 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF lists this award's end date as 31 August 2028.
NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 29 December 2028.

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Award card

Award number: 2530370
Period of support: 1 Sep 2025 – 31 Aug 2028
Amount: $999,626
Awardee: Cleveland Clinic Foundation, Cleveland, OH
Program: Genetic Mechanisms
Directorate: BIO

Abstract

The DNA of organisms from yeast to humans is packaged in linear chromosomes, the ends of which are called telomeres. When chromosomes are broken, the broken ends can be degraded or fused with other chromosomes to cause mutations and diseases such as cancer. Broken chromosomes and telomeres both present DNA ends, but telomeres have special DNA sequences and proteins bound to them that block degradation and fusion.…

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