NSF award 2531171 · Case Western Reserve University

Molecular interactions required for targeting mRNA to nonsense-mediated decay.

Final report due

29 December 2028

in 803 days · The award ends on 31 August 2028.

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award ending 2028-08-31 · Research.gov
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Extension request17 Jul 2028in 638 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice21 Aug 2028in 673 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2028in 803 days
award ending 2028-08-31 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF lists this award's end date as 31 August 2028.
NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 29 December 2028.

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Award card

Award number: 2531171
Period of support: 1 Sep 2025 – 31 Aug 2028
Amount: $1,014,796
Awardee: Case Western Reserve University, Cleveland, OH
Program: Genetic Mechanisms
Directorate: BIO

Abstract

Cells have evolved sophisticated strategies to ensure the accurate expression of genetic information and safeguard against potentially harmful effects of defective messenger RNA (mRNA) and proteins. One such strategy recognizes mRNA translation events that terminate prematurely and targets the faulty mRNA transcript for rapid degradation. This critical quality control activity prevents accumulation of unproductive…

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