NSF award 2533077 · University of California-Berkeley

BioMADE: Development of genomic language models to predict optimal genomes for commercial protein production

Final report due

29 December 2027

in 437 days · The award ends on 31 August 2027.

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Decide about an extension3 May 2027in 197 days
award ending 2027-08-31 · Research.gov
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Extension request17 Jul 2027in 272 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice21 Aug 2027in 307 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2027in 437 days
award ending 2027-08-31 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF lists this award's end date as 31 August 2027.
NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 29 December 2027.

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Award card

Award number: 2533077
Period of support: 1 Sep 2025 – 31 Aug 2027
Amount: $449,999
Awardee: University of California-Berkeley, Berkeley, CA
Program: Cellular & Biochem Engineering, Cross-BIO Activities, Systems and Synthetic Biology
Directorate: ENG

Abstract

Microbes are being used to produce a range of products. Some of those products are proteins, such as insulin or blood-clotting factors. In many cases, fungal strains are used because they have protein secretion systems. However, the secretion systems are not optimized for throughput, so strain improvement is needed. To facilitate this process, AI methods will be employed to develop a digital model that emulates most…

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