NSF award 2534080 · University of Pennsylvania

Collaborative Research: Imaging the transition: Temporal control of zygotic genome activation by the nuclear to cytoplasmic ratio

Final report due

28 August 2030

in 1,410 days · The award ends on 30 April 2030.

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Award card

Award number: 2534080
Period of support: 1 May 2026 – 30 Apr 2030
Amount: $622,842
Awardee: University of Pennsylvania, Philadelphia, PA
Program: Molecular Biosciences
Directorate: BIO

Abstract

Early embryonic development is characterized by a dramatic transition from cellular dependence on RNAs that were in the egg prior to fertilization to RNAs produced by the embryo itself. This process is known as zygotic genome activation (ZGA). The timing of ZGA is linked to changes in cell size, specifically the ratio of nuclear content (DNA) to cytoplasmic volume (also known as the nuclear-to-cytoplasmic or N/C…

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