NSF award 2541118 · University of Illinois at Chicago

CAREER: An investigation of the role of Piezo1 polymorphisms in traumatic brain injury pathology using isogenic human in vitro models

Final report due

28 August 2031

in 1,775 days · The award ends on 30 April 2031.

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So the final report is due by 28 August 2031.

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Award card

Award number: 2541118
Period of support: 1 May 2026 – 30 Apr 2031
Amount: $599,999
Awardee: University of Illinois at Chicago, Chicago, IL
Program: Engineering of Biomed Systems
Directorate: ENG

Abstract

The protein Piezo1 in human body allows cells to feel mechanical forces such as stress, strain, and trauma. Cells use Piezo1 to drive the sense of touch and direct joints, muscles, and tendons to gain strength when they are overloaded. E756del is a genetic variant in the gene for Piezo1 and those who have this variant are highly sensitive to mechanical load. For example, athletes with this variant develop stronger…

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