NSF award 2542492 · University of Notre Dame

CAREER: Mechanisms of Tumor Growth-Induced Immunomechanical Dysfunction

Final report due

28 October 2031

in 1,836 days · The award ends on 30 June 2031.

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Decide about an extension2 Mar 2031in 1596 days
award ending 2031-06-30 · Research.gov
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Extension request16 May 2031in 1671 days
award ending 2031-06-30 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice20 Jun 2031in 1706 days
award ending 2031-06-30 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due28 Oct 2031in 1836 days
award ending 2031-06-30 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due28 Oct 2031in 1836 days
award ending 2031-06-30 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out28 Oct 2031in 1836 days
award ending 2031-06-30 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF lists this award's end date as 30 June 2031.
NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 28 October 2031.

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Award card

Award number: 2542492
Period of support: 1 Jul 2026 – 30 Jun 2031
Amount: $555,135
Awardee: University of Notre Dame, Notre Dame, IN
Program: Engineering of Biomed Systems, BMMB-Biomech & Mechanobiology
Directorate: ENG

Abstract

The immune system plays a critical role in protecting the body from disease. However, in the context of cancer, the immune system becomes ineffective at recognizing and eliminating tumor cells. One important and often overlooked reason for this failure is that tumors pose not only biological but also physical challenges. As tumors grow, they generate crowding and pressure that physically squeeze nearby cells and…

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