NSF award 2552994 · Regents of the University of Michigan - Dearborn

ERI: Engineering perivascular microphysiological systems to discover hydrodynamic signatures of neurodegeneration

Final report due

28 August 2028

in 680 days · The award ends on 30 April 2028.

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Decide about an extension1 Jan 2028in 440 days
award ending 2028-04-30 · Research.gov
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Extension request16 Mar 2028in 515 days
award ending 2028-04-30 · Research.gov
PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice20 Apr 2028in 550 days
award ending 2028-04-30 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due28 Aug 2028in 680 days
award ending 2028-04-30 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due28 Aug 2028in 680 days
award ending 2028-04-30 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out28 Aug 2028in 680 days
award ending 2028-04-30 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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NSF lists this award's end date as 30 April 2028.
NSF rules say the final report is due no later than 120 days after that.
So the final report is due by 28 August 2028.

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Award card

Award number: 2552994
Period of support: 15 May 2026 – 30 Apr 2028
Amount: $199,991
Awardee: Regents of the University of Michigan - Dearborn, Dearborn, MI
Program: Special Initiatives
Directorate: ENG

Abstract

Incurable brain diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS), are caused by an unhealthy buildup of normal brain waste proteins. Recent research has shown that the brain uses cerebrospinal fluid (CSF), a clear fluid that surrounds and cushions the brain, to flush out these wastes. Waste proteins often build up around arteries, where the fluid pulses with each heartbeat, but…

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