NSF award 2612552 · James Madison University

RUI: Probing obscurin's role as a mechanotransducer

Final report due

29 December 2030

in 1,533 days · The award ends on 31 August 2030.

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PAPPG 24-1: “at least 45 days prior to the end date”
No-cost extension notice21 Aug 2030in 1403 days
award ending 2030-08-31 · Research.gov
PAPPG 24-1: “at least ten calendar days prior to the end date”
Final report due29 Dec 2030in 1533 days
award ending 2030-08-31 · Research.gov
PAPPG 24-1: “no later than 120-days following the end date of the award”
Project outcomes report due29 Dec 2030in 1533 days
award ending 2030-08-31 · Research.gov
PAPPG 24-1: “no later than 120 days following the end date”
Award is closed out29 Dec 2030in 1533 days
award ending 2030-08-31 · Research.gov
PAPPG 24-1: “financially closed out 120 days after their expiration date”

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So the final report is due by 29 December 2030.

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Award card

Award number: 2612552
Period of support: 1 Sep 2026 – 31 Aug 2030
Amount: $870,218
Awardee: James Madison University, Harrisonburg, VA
Program: Cell, Dev, & Physio
Directorate: BIO

Abstract

Some cells must migrate throughout the body - this is how wounds heal and how organs develop in the correct spot. However, cells that migrate when they shouldn’t are a hallmark of cancer metastasis. Surprisingly little is known about how human cells decide to migrate. This project will investigate a protein named “obscurin” that prevents cells from migrating within the body. When obscurin is missing or mutated,…

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